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Full-text paper (pdf): mutations in the paralogous human α-globin genes yielding identical hemoglobin variants. Hb hekinan chinese (macau) 1 128 jewish (brazilian) 1 126 79 18 (α212 and α121) are most likely the result of a single crossover between a normal and.
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The human α-globin genes are paralogues, sharing a high degree of dna sequence similarity and producing an identical α-globin chain over half of the α-globin structural variants reported to. Having a single genetic variant for thalassemia may protect against malaria and thus be an advantage people diagnosed with heterozygous (carrier).